MOTS-c

Order MOTS-c peptide from Purita Peptides. Purchase MOTS-c peptide with verified 99% purity, independent laboratory testing and documented batch quality control for consistent research-grade performance.

• 10mg
• 40mg

The only known signalling peptide encoded by mitochondrial DNA rather than nuclear DNA. MOTS-c is a 16-amino acid peptide discovered in 2015 that fundamentally changed how researchers understand mitochondrial communication. Under conditions of metabolic stress, it translocates from the mitochondria to the cell nucleus where it directly regulates genes involved in energy metabolism, insulin sensitivity, and stress response. This nucleus-mitochondria communication loop was not previously known to exist for a peptide of this class. Levels decline naturally with age across both animal and human plasma data, which has made it relevant not only as a research compound but as a potential biomarker of metabolic ageing. A March 2026 study from the University of Copenhagen confirmed MOTS-c augments muscle mitochondrial bioenergetic performance through both PGC-1alpha and AMPK pathways. A separate 2025 study showed restored mitochondrial respiration in diabetic cardiac tissue models at a subcellular level. The 10mg pen suits standard protocols. The 40mg pen is designed for extended research cycles.