Semax
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The Russian CNS peptide that Western science is only now catching up on. Semax is a synthetic heptapeptide derived from ACTH, the pituitary stress hormone, but without its hormonal effects. Its primary mechanism is the upregulation of BDNF, one of the most critical growth factors in the brain, governing neuronal survival, synaptic plasticity, and cognitive function at a cellular level. Originally developed at the Institute of Molecular Genetics in Moscow and used clinically in Russia for decades in stroke recovery and cognitive decline treatment. A 2025 study also identified a second distinct mechanism, confirming Semax as a copper chelator capable of reducing oxidative stress generated by amyloid-beta complexes, opening a new dimension of research interest in neurodegeneration models. Most commonly studied alongside Selank for combined neuroprotective and CNS regulatory research.